Speed Climber

Beat the Spire (an Act 3 win) in under 20 minutes of in-run time. Speed comes from ending fights fast and not dawdling on maps and menus. An aggressive high-damage deck (Silent Poison or Ironclad Strength) that bursts fights down helps, and a low Ascension keeps enemy HP low. Skip card rewards you don't need (fewer choices = less time), beeline the shortest map path, and play briskly. A run seeded with an early damage engine makes this comfortable - the timer is generous if you're not dithering.