Minimalist

Win with a deck of 5 cards or fewer. You start with 10-12 cards, so this is all about aggressive removal: take card-removal at every shop, and every Purge/removal event you can, skip almost all card rewards, and lean on relics and potions for power instead of cards. A couple of strong cards plus good relics carries it. Pairs perfectly with Purity and Who Needs Relics? on one minimalist run, and a lower Ascension makes the thin deck survivable.