You Are Nothing

Kill a boss during turn 1, before it gets to act. You need a burst deck that can dump enough damage in one turn to delete a boss's full HP bar (~250 for a low-HP Act 1 boss). Realistic setups: a stacked Ironclad Strength turn (Spot Weakness/Inflame/Flex into Heavy Blade or Reaper), or a Watcher Wrath burst. Pick a low-HP boss - Slime Boss or Hexaghost at a low Ascension - build the deck across the run, then unload turn 1. Doubles up nicely with Perfect.