No time to die

Beat the game on Permadeath - one life, death ends the run. Do it as its own playthrough. Over-level in the safe early areas before you push on, always carry a fat stack of healing potions, pull enemies one at a time with a bow or terrain, and steer clear of packs and the ambushes you already know about. No save-scumming to bail you out, so play patient. A route you know cold from earlier runs makes this far less scary than it sounds.