Are there missable achievements in HunieCam Studio?

Yes, 7: Diligent Degeneracy, Platinum Porksword, Gold Gearshift, Diamond D-train, Catch 'Em All, Silver Skinflute and Bronze Babymaker.

HunieCam Studio achievement guide, roadmap and tracker

Entrepreneur

Very common83.9%

ObjectiveUnmissable

Employ your very first cam girl.

You'll get this pretty much as soon as you start; put your first girl in the cam building and it'll pop.

Harem (Strictly Professional)

Common44.0%

ObjectiveOptional

Employ a full staff of 8 cam girls.

Do this at the same time as Brand Loyalty (i.e. pick the 8 original HuniePop characters as your 8)

Diversity Day

Uncommon36.8%

ObjectiveOptional

Have one girl of each race doing a cam show simultaneously.

Guilty Pleasures

Uncommon36.5%

ObjectiveOptional

Unlock all outfits and hairstyles for one girl.

Shill King

Uncommon28.7%

ObjectiveOptional

Purchase 8 ads within a single day.

Diligent Degeneracy

Uncommon23.9%

ObjectiveMissable

Complete a game session without dropping below 5 cigs or drinks.

Stick with Kyanna, Tiffany and Nikki so you don't need cigs/booze and this should be easy enough :)

Platinum Porksword

Uncommon22.5%

ObjectiveMissable

Earn the Platinum trophy.

Gold Gearshift

Uncommon16.6%

ObjectiveMissable

Earn the Gold trophy without escorting.

Diamond D-train

Uncommon15.2%

ObjectiveMissable

Earn the Diamond trophy.

Brand Loyalty

Uncommon13.0%

ObjectiveOptional

Employ a full staff made up entirely of HuniePop characters.

Keep hiring until you get all of the following girls and then put them all active in your squad at the same time: Nikki, Kyanna, Tiffany, Beli, Audrey, Aiko, Lola and Jesse. You can get rid of them afterwards if you want.

Wolf Of Ball Skeet

Uncommon11.4%

ObjectiveOptional

Purchase every investment within 21 days.

Catch 'Em All

Uncommon11.1%

All-the-thingsMissable

Contract all 6 STDs (within a single save file).

Disappoint Your Parents

Rare9.9%

All-the-thingsOptional

Unlock all outfits and hairstyles for all girls.

Silver Skinflute

Rare9.3%

ObjectiveMissable

Earn the Silver trophy using only 3 girls.

Don't hire any more than 3 (whether you activate them or not). Stick with Kyanna, Tiffany and Nikki so you don't need cigs/booze and this should be easy enough.