Vampyr

A scripted story beat - a boat ride with your colleague Edgar Swansea as part of the main quest. Unmissable, comes on its own, nothing to seek out.

A missable choice - when you first meet Clay Cox, choose to spare him rather than putting him down. Save just before the encounter so you can pick the merciful option on purpose; kill him and it's gone for that save.

Resolving Dorothy Crane's storyline - another choice-driven outcome. Progress her questline to the decision point; save first if you're aiming for a particular ending for her.

Fergal, the Skal boss down in the sewers - a story fight. Same approach: come in over-levelled if you can, stun-and-bite to sustain your blood, dodge the lunges, and keep serums topped up.

Resolving Sean Hampton's storyline - a choice-driven outcome. Work through his questline and you'll reach the decision that settles his fate and pops this. Save beforehand if you want to steer which way it goes.

A story-gated boss fight. Vampyr bosses are level-checks more than skill-checks - if you hit a wall, you're under-levelled, and the quickest fix is embracing a citizen or two for a big XP spike (at the cost of that district's health). In the fight itself, open with a Blood Spear stun then bite to refill blood, keep healing serums stocked, and dodge the big wind-ups rather than trading blows.

Another story-gated fight. Same rules: stay levelled (embrace a citizen for XP if you're struggling), stun with Blood Spear, bite to recover blood mid-fight, and dodge the heavy hits rather than blocking. Bring anti-stun and healing serums.

The showdown with the vampire-hunter leader McCullum. Win it and this pops - and afterwards you get the choice to finish or spare him (a story branch, not tied to this one). Fight it like any Vampyr boss: keep your level up, stun-then-bite to sustain, dodge the big swings.

Resolving Edgar Swansea's arc - a story choice that comes late as his storyline concludes. Save before the decision if you're chasing a specific outcome.

A main-path boss. If it's shredding you, you're under-levelled - a couple of embraces close the gap fast. Stun with Blood Spear, bite to top up blood, keep healing serums on hand and dodge the heavy attacks.

Story-complete - pops when you finish the game, so it's unmissable on any run. Which of the endings you land doesn't matter for this one.

A lore pickup tied to the main investigation into the ancient vampire Paulus Aurelianus. It comes as the late-game questline sends you after his past - follow the main quest and search the area it points you to.