Difficulty doesn't affect achievements - even God Mode which, contrary to the name, doesn't make you invincible but instead just reduces damage (up to a maximum 80% damage reduction).
Clear Tartarus
Clear Tartarus
Clear Asphodel
Clear Asphodel
Unlock each of the Infernal Arms
Unlock each of the Infernal Arms
Use Greater Call to invoke an Olympian's aid
Use Greater Call to invoke an Olympian's aid
Clear Elysium
Clear Elysium
Fulfill the 'Chthonic Colleagues' Prophecy
Fulfill the 'Chthonic Colleagues' Prophecy
Clear an escape attempt
Clear an escape attempt
Beat Thanatos by 15 kills or more
Beat Thanatos by 15 kills or more
Slay Skelly 15 times
Slay Skelly 15 times
Buy 9 'Well of Charon' items in one escape attempt
Buy 9 'Well of Charon' items in one escape attempt
Pet Cerberus 10 times
Pet Cerberus 10 times
Trade 20 times with the Wretched Broker
Trade 20 times with the Wretched Broker
Earn access to and enter the Administrative Chamber
Earn access to and enter the Administrative Chamber
Choose 100 different Olympian Boon effects
Choose 100 different Olympian Boon effects
Max any Weapon Aspect
Max any Weapon Aspect
Compel Orpheus to sing again
Compel Orpheus to sing again
Forge a bond with any character
Forge a bond with any character
Catch a fish from each region
Catch a fish from each region
Pay for 50 jobs from the House Contractor
Pay for 50 jobs from the House Contractor
Complete the main quest in the story
Complete the main quest in the story
Fulfill any 15 Prophecies
Fulfill any 15 Prophecies
Earn a Loyalty Card
Earn a Loyalty Card
Choose 50 different Daedalus Hammer enchantments
Choose 50 different Daedalus Hammer enchantments
Equip a Chthonic Companion
Equip a Chthonic Companion
Fulfill the 'Master of Arms' Prophecy
Fulfill the 'Master of Arms' Prophecy
Clear an escape attempt with a hidden Weapon Aspect
Clear an escape attempt with a hidden Weapon Aspect
Unlock each standard Keepsake
Unlock each standard Keepsake
Clear an Erebus Gate without taking damage
Clear an Erebus Gate without taking damage
Fully Unlock the Olympians' Codex entries
Fully Unlock the Olympians' Codex entries
Fulfill the 'War-God's Bloodlust' Prophecy
Fulfill the 'War-God's Bloodlust' Prophecy
Clear Elysium with the 'Extreme Measures' Condition
Clear Elysium with the 'Extreme Measures' Condition
Fulfill the 'Musician and Muse' Prophecy
Fulfill the 'Musician and Muse' Prophecy
Get 20% dodge chance with the Lambent Plume
Get 20% dodge chance with the Lambent Plume
Use an Olympian's Greater Call against them in a Trial
Use an Olympian's Greater Call against them in a Trial
Earn the first of Skelly's prizes
Earn the first of Skelly's prizes
Purge a Legendary Boon
Purge a Legendary Boon
Fulfill the 'Slashed Benefits' Prophecy
Fulfill the 'Slashed Benefits' Prophecy
Have at least one rank in each Mirror of Night Talent
Have at least one rank in each Mirror of Night Talent
Fulfill the 'Night and Darkness' Prophecy
Fulfill the 'Night and Darkness' Prophecy
Fulfill the 'End to Torment' Prophecy
Fulfill the 'End to Torment' Prophecy
Unlock all Weapon Aspects
Unlock all Weapon Aspects
Fulfill the 'Dark Reflections' Prophecy
Fulfill the 'Dark Reflections' Prophecy
Fulfill the 'Divided by Death' Prophecy
Fulfill the 'Divided by Death' Prophecy
Reach the epilogue of the story
Reach the epilogue of the story
Fulfill the 'Harsh Conditions' Prophecy
Fulfill the 'Harsh Conditions' Prophecy
Get 30% bonus damage with the Pierced Butterfly
Get 30% bonus damage with the Pierced Butterfly
Earn the second of Skelly's prizes
Earn the second of Skelly's prizes
Earn all Chthonic Companions
Earn all Chthonic Companions
Max-rank each standard Keepsake
Max-rank each standard Keepsake