No missable achievements (plus 125 unknown)
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Defeat Green Goblin in the Prologue
Defeat Doctor Octopus in Chapter 1
Defeat The Hood in Chapter 2.
Defeat Elektra in Chapter 3.
Defeat The Kingpin in Chapter 4.
Defeat Juggernaut in Chapter 5.
Defeat Magneto in Chapter 6.
Defeat Mister Sinister in Chapter 7.
Find and Defeat a Cosmic Doop
Defeat Doctor Doom in Chapter 8.
Defeat 10 different members of the Sinister Six.
Defeat Loki in Chapter 9.
Reach level 60 with any hero.
Complete 24 different Alerts in Story missions.
Level any vendor to level 10.
Defeat 7 Different Super Villians in their Showdowns
Complete the Super Heroic Trial with any hero.
Visit Six Different Headquarters
Collect any 100 Relics of the same type
Defeat 150 Super Villains in Midtown Manhattan.
Loot a Cosmic Medallion
Defeat a Training Room Target Dummy.
Complete the Cosmic Trial with any hero.
Prestige any Hero.
Loot 100 Artifacts.
Get Five Heroes to Level 60.
Complete 14 Different Operations
Complete 50 Legendary Quests.
Loot 1,000,000 Credits.
Rescue 100 civilians in Midtown Patrol.
Open 50 Bounty Chests in Operations
Prestige any Hero twice.
Apply a Modification to an Artifact.
Explore all of the Treasure Rooms in each chapter of Story Missions.
Alone, defeat Shocker in under 50 seconds upon entering the Abandoned Subway Operation.
Fully upgrade a Legendary Item.
Earned all other Marvel Heroes Omega achievements.