No missable achievements (plus 50 unknown)
Sign in with Steam or Xbox to track your progress, and:
Complete level 1.
Complete level 2.
Complete 5 missions.
Use a Continue.
Complete level 3.
Complete level 4.
Complete 20 missions.
Complete level 5.
Equip a gold glyph.
Defeat 1,000 creatures with special kills.
In a single combat, generate 60 reflected projectiles by shooting at a reflective-aura protected creature.
Clear every challenge type once.
Play with an alternate outfit.
Upgrade the same glyph twice in a single playthrough.
Finish the game in Normal mode with Aeon.
In a single playthrough, take no damage in a 3-skull combat card. Do this 10 times.
Kill 7,500 creatures.
Finish the game in Normal mode with Mukai.
Finish the game in Normal mode with Big Mo.
Accept 30 combat modifiers.
Kill 13 creatures with a single blow.
Finish the game with at least 7 keys, 7 energy cells and 1,500 mana.
Finish the game in Normal mode with Rasimov.
In a single playthrough, upgrade 6 skills from each of the three skill trees, and equip a gold glyph.
Complete 72 missions.
Survive the secret Cthulhu card in Hard mode
Survive a One-Shot Kill card in which you lost health.
Equip each of the 23 glyphs.
Clear a level with special kills only.
Finish the game in Hard mode with Aeon.
In a single playthrough, purchase 20 items in shops.
Playing Mukai, finish the game by entering every card of every level (not counting extra cards or the shortcut card)
Finish the game in Hard mode with Mukai.
Finish the game in Hard mode with Rasimov.
Have 15 health.
Unlock all of Aeon's permanent upgrades.
Finish the game in Hard mode with Big Mo.
In a single playthrough, reroll 3 shops, bypass 2 cards, and cast destiny runes once.
Playing Big Mo, finish the game without overheating once.
Unlock all of Mukai's permanent upgrades.
Unlock all of Big Mo's permanent upgrades.
In level 4, be within the range of a doll head's swirl of minions for 20 seconds.
Unlock all of Rasimov's permanent upgrades.
Playing Aeon, finish the game by using Shadow Bolt to deal the killing blow on each of the guardians.
View every fate in the game.
Finish the game without using any glyph.
Complete 120 missions.
Finish the game without opening a single locked chest or locked card.
Finish the game without purchasing a single skill upgrade.
Playing Rasimov, activate the Immortal ability 6 times and finish the game with full health.