No missable achievements (plus 53 unknown)
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Acquire the Mystic.
Use a merchant to repair an item.
Kill the Skeleton King.
Kill the Butcher.
Socket a gem in an item.
Complete all quests in Act I.
Craft 5 items.
Kill Zoltun Kulle.
Raise the Mystic to level 12.
Pick up 500,000 gold.
Kill the Siegebreaker Assault Beast.
Kill 500 elite (champion, rare, or unique) enemies.
Complete all quests in Act II.
Replace a property with Enchanting.
Complete 5 Bounties.
Complete all quests in Act IV.
Complete all quests in Act III.
Kill 500 Monsters while in Nephalem Rifts.
Reach level 70.
Raise the Blacksmith to level 12.
Complete all quests in Act V.
Raise the Jeweler to level 12.
Recruit the Templar, Scoundrel, and Enchantress.
Finish a Nephalem Rift within 15 Minutes.
Craft 100 items.
Get a destruction callout for breaking 50 objects.
Equip all Inventory slots with Legendary items that have a minimum required level of 70 or higher.
Kill 100 Treasure Goblins.
Enchant all your equipment slots.
Reach level 70 with 6 different classes.
Reach level 70 with a Necromancer.
Kill 1,000 Undead enemies with corpses.
Kill Diablo in Hardcore mode.
Kill Malthael in Hardcore mode.
Reach level 70 in Hardcore mode.
Complete Act V with a Necromancer.
Complete 500 Bounties.
Damage 40 enemies with Bone Spear in 3 seconds.
Use Bone Armor to rip the Bones from the Skeleton King.
Kill 5,000 cursed enemies.
Kill 500 elite (champion, rare, or unique) enemies with Command Skeletons minions.
Listen to all of Master Ordan's conversations in the Pandemonium Fortress.
While under 10% life and fighting Diablo, use an ability that costs health and then defeat him.
Kill your own Shadow Clone with Simulacrum during the Diablo encounter.