No missable achievements (plus 45 unknown)
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Completed Level 1 - Sand Central Station
Complete first Helicarrier skydive
Turned Mister Fantastic into a teapot for the first time
Completed Level 2 - Times Square Off
Completed Level 3 - Exploratory Laboratory
Completed Level 4 - Rock up at the Lock up
Regenerated as Wolverine
Completed Level 5 - Rebooted, Resuited
Completed Level 6 - Red Head Detention
Completed Level 7 - Bifrosty Reception
Completed Level 8 - Juggernauts and Crosses
Completed Level 9 - Doctor in the House
Completed Level 10 - That Sinking Feeling
Completed Level 11 - Taking Liberties
Completed Level 12 - Rapturous Rise
Completed Level 13 - Magnetic Personality
Created a custom character
Completed Level 14 - A Doom with a View
Completed Level 15 - The Good, the Bad and the Hungry
Played as Agent Coulson
Teamed up Captain America with Human Torch (Co-op)
Destroyed 100 vehicles in the Manhattan hub
Collected Howard the Duck (Single Player)
Completed House Party Protocol
Unlocked Black Cat (Single Player)
Defeated 100 enemies as the Thing
Collected all Iron Man armors (Single Player)
Transformed into the Hulk 50 times
Unlocked all the Guardians of the Galaxy (Single Player)
Collected all Avengers characters in the game (Single Player)
Collected all traditionally evil mutants (Single Player)
Collected Doc Ock, Sandman, Mysterio, Kraven the Hunter, Electro and Vulture (Single Player)
Collected 1,000,000,000 studs (Single Player)
Read a comic in Deadpool's room on the Helicarrier
Unlocked all animal-themed characters (Single Player)
Collected all traditionally heroic mutants (Single Player)
Unlocked all True Believers (Single Player)
Turned into Stan Hulk
Rescued Stan Lee from every peril (Single Player)
Performed a special throwing move as Colossus on Wolverine
Created a character called “Trevor” in the character customizer
Performed Hulk's special move on Loki
Performed all big LEGO figure transformations
Drove to the Baxter Building as Magneto in the Magneto Mobile
Completed game 100% (Single Player)