No missable achievements (plus 62 unknown)
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Find Fred's basement workshop
Close a door
Pick up 15 things that don't belong to you
Create a cherry tree
Destroy a cherry tree
Play Maniac Mansion
Open the safe
Hoagie eats a Hoagie
Make it rain
Pick up 30 things that don't belong to you
Change the flag
Clothe Laverne in the costume
Get all six novelty items
Deflate Oozo
Make vinegar
Climb through the chimney with all three kids
Enter the human contest
Microwave the frozen hamster
Red makes a super battery with only a little help from Hoagie
Disqualify Harold
Wake up Dr. Fred
Make a skunk
Get a tiny sweater
Return the stamp album to Weird Ed
Power Hoagie's Chron-o-John
Get Fred to sign the contract
Pick up 45 things that don't belong to you
Acquire a diamond
Vacuum up a hamster
Power Laverne's Chron-O-John
Defeat Purple Tentacle yesterday
Play the whole game without skipping a cutscene
Turn off the television
Ask the IRS agents if they're related
Sit through the end credits
Try to mix the decaf and caffeinated coffees
Get a job
Talk to Dead Cousin Ted with all three kids
Try to put something metal in the microwave
Try to mix the disappearing ink with Booboo-B-Gone
Win the human contest
Ring the front desk bell 100 times
Try to microwave the hamster again after he's thawed out
Try to flush the hamster
Try to alter the contract with Booboo-B-Gone
Squirt five different people with disappearing ink
Try to wash the dirty car with the brush
Try to swap the textbook with the stamp album
Try to mix the red paint and the Booboo-B-Gone
Hoagie uses battery with Chron-O-John instead of plug
Laverne tries the chattering teeth on her human during the human show
Try to sign the contract yourself with the quill pen
Flush 50 objects through time
Laverne thinks about eating the cat
Reach yesterday without turning the stereo off
Cook the hamster in Maniac Mansion (Don't try this at home, kids!)
Talk to Washington, Jefferson, or Hancock while they're outside
Get all other achievements in the game