No missable achievements (plus 62 unknown)
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Enter Level 1.
Run out of ammo once.
Collect every Basic Weapon at least once in one level.
Defeat Leader Red.
Defeat Angry Alex.
Enter Level 2.
Take 200 Damage and still complete a level.
Get nine or more standard weapon powerups while using an alternate default gun.
Defeat Leader Yellow last.
Get 200% Phase.
Enter Level 3.
Beat a level without dashing.
Beat a level without losing a Battery.
Defeat Leader Green last.
Enter Level 4.
Beat Level 4.
Get 300,000 points in a level.
Enter Level 5.
Defeat Leader Blue last.
Defeat the Moon Man.
Beat Level 5.
Beat Rainbow Rush in less than 2:45.
Defeat Leader Orange last.
Collect the Missle Launcher 5 Times or Defeat Leader Red as Leader Red.
Beat the Moon Man without destroying the Moon Bike.
Beat Leader Red while in a red reality.
Attack more than 200 times while battling Leader Orange.
Defeat Leader Blue without letting him or Leader Orange drop below 50% shields at the same time.
Don't fall off the road before reaching Leader Green, then defeat Leader Green.
Use the Gatling Gun 4000 Times or collect it 3 times.
Dash 300 times (lifetime).
Run out of ammo more than 50 times (lifetime).
Use the Flamethrower 1400 Times or collect it 3 times.
Defeat Leader Green while dealing less than 5% damage to Leader Yellow, then defeat Leader Yellow.
Complete a level without getting overcharge.
Defeat Leader Purple.
Get 3,000,000 points (lifetime).
Beat a level while in a red reality where your HP is halved.
Beat the game in under 45 minutes.
Beat Rainbow Rush with at least one full segment of the reality meter red.
Destroy 75% of Agent Silva's text bubbles.
Use the Moon Rifle 370 Times or collect it 3 times.
Collect the Remote Sentries 5 Times or Defeat Leader Purple as Leader Purple.
Collect the Variable Cannon 5 Times or Defeat Leader Orange as Leader Orange.
Beat the game without running out of ammo.
Destroy 5000 enemies, then show the Moon Man (and his bike) who's boss.
Collect the Barrier Gun 5 Times or Defeat Leader Green as Leader Green.
Beat the game without falling off the road once. Alternatively, fall off the road more than 200 times.
Get 3 Extra Batteries in one level.
Collect the Energy Saber 5 Times or Defeat Leader Yellow as Leader Yellow.
Use the Rainbow Sentries 380 Times or collect it 3 times.
Beat the game without dashing.
Collect the Psycho Cannon 5 Times or Defeat Leader Blue as Leader Blue.
Pick up 1,000 Shield powerups (lifetime).
Collect 400 Ammo powerups (lifetime).
Beat the game as Agent Silva.
Use the Satellite Remote 150 Times or collect it 3 times.
Beat the game without losing a Battery.
Destroy almost every text box in the game at least once.